Running a 48v system in my motorhome and went through exactly this sizing exercise last year.
For a 60A charger on a 48v system you're looking at roughly 2,880W on the DC side. The general rule of thumb I follow is fuse at 125% of continuous rated current, so that puts you at 75A minimum — meaning a 80A or 100A ANL fuse is typically the sensible choice depending on cable run length and gauge.
A few things worth considering:
- Cable length matters — longer runs have more resistance and you may want to upsize the cable (and potentially the fuse accordingly)
- Wire gauge — if you're running 16mm² or 25mm², that changes the picture for thermal protection
- Charger inrush — some chargers have a brief startup surge; Victron units are pretty well-behaved here but worth checking your specific model's datasheet
I'm running a Victron MultiPlus-II and went with a 100A MEGA fuse close to the battery terminals on both positive feeds. Victron's own documentation actually recommends this sizing for similar setups, which gave me confidence.
The Fogstar and EVE cell community tends to use 100A ANL fuses as a sensible sweet spot for this power level — protects the wiring without nuisance tripping.
What charger are you running and what's your cable setup looking like? That'll help narrow it down properly. Others here will likely have direct experience with your specific unit too.