Been wrestling with a similar headache on my emergency backup array and thought it worth raising here.
Running a Victron SmartSolar 100|20 with a pair of panels wired in series — nothing exotic, standard UK install. Started getting nuisance fuse failures on the PV input side, which immediately made me suspicious of transient overcurrent events rather than a genuine dead short.
A few things I'd check straight away if you're seeing repeated fuse blows:
1. Actual Voc under cold conditions
In the UK, ambient temps regularly push real-world Voc noticeably above STC figures. If your series string is already nudging the controller's 100V input ceiling on a cold clear morning, you've got a problem waiting to happen.
2. Wiring gauge and connector condition
Undersized cable creates resistance, which under load generates heat, which can cause intermittent high-resistance faults that stress protection components. Check every MC4 connection is properly crimped — Renogy's cheaper connectors have let me down before.
3. Fuse rating vs. Isc
The 20A output rating doesn't necessarily reflect what the fuse is protecting. Verify your replacement fuse spec matches what Victron actually specifies in the manual, not what someone assumed was "close enough."
4. Ground fault possibility
A partial ground fault on the panel frame — particularly on metal-framed installs outdoors year-round — can cause exactly this symptom intermittently.
On my setup, the culprit turned out to be a corroded MC4 joint creating a resistive hot-spot. Replaced with quality IP68-rated connectors and haven't had a fuse failure since.
Anyone else seen repeated fuse events on their MPPT controllers