Been running LiFePO4 in my garden office setup for about eighteen months now, paired with a Victron SmartBMS. The jump from AGM was worth every penny.
Key thing nobody's mentioned yet — temperature. My batteries live in an unheated outbuilding. LiFePO4 gets grumpy below 0°C (won't charge properly), whereas my old AGMs didn't care. Sorted it with a cheap stick heater on a thermostat, but it's a real consideration if you're off-grid somewhere cold.
The DoD advantage is genuinely massive though. I was replacing AGM packs every four years. LiFePO4 should go ten-plus if you're not hammering it flat constantly.
Budget-wise, yeah, you need the right kit. But honestly? A basic Victron MPPT and a decent BMS costs less than replacing AGM twice. False economy keeping old chemistry.
Also got a smaller Fogstar 48V setup on the boat for weekends — same reliability, just different form factor.
If your usage is steady and you can sort the charger compatibility, LiFePO4 wins. Only stick with AGM if you've genuinely got physical space or thermal constraints.