The lines do blur a bit, don't they? I've had both over the years, and honestly the electrical side is where you notice the real difference.
My old campervan was pretty basic — leisure battery, split charger, maybe 400W of solar on the roof if you were lucky. The motorhome I'm in now is a different beast entirely. Better insulation means the battery gets worked harder in winter, so I've had to step up my charging game considerably. Went with a Victron MPPT controller and doubled my panel capacity because the van was just draining down too quickly.
The other thing that shifted my thinking was auxiliary power. The motorhome has more creature comforts — water pump, heating, built-in leisure fridge — all drawing current when you're not plugged in. Campervans tend to be more minimalist, which actually makes them easier to spec for off-grid. Less to manage, fewer failure points.
What I'd say is: work backwards from your actual usage. How many days between hook-ups? What are you actually running? A motorhome might need a proper lithium setup with decent inverter capacity; a stripped-out campervan might just need a decent lead-acid system and some solar.
I'm genuinely curious how others have approached this — especially those who've retrofitted their own systems. Are you planning a build, or already living with one of these setups? The devil's really in the details of what you want to power and how often you'll be off-grid.