Been running a Victron Orion-Tr Smart 12/12-30A on the narrowboat for about two years now, pulling from the engine alternator into a 200Ah Fogstar LiFePO4 bank — honestly it's the single best upgrade I've made for emergency backup when solar goes rubbish (so, November through March then).
The thing that catches people out is the isolated vs non-isolated question. On a boat you absolutely want isolated to avoid galvanic corrosion eating your hull, but for a car-to-leisure-battery setup it's less critical — just make sure you're not sharing a common negative doing something daft.
Also worth flagging for anyone shopping around: the cheap Amazon units (you know the ones, generic branding, suspiciously round numbers on every spec) tend to not play nicely with LiFePO4 because they don't properly tail off the charge when the alternator voltage drops under load. Victron's the gold standard but Renogy's DC-DC units are decent value if the budget's tight.
One gotcha nobody mentions — smart alternators on modern cars (anything post ~2012 really) vary their output voltage intentionally to recover braking energy, which confuses a basic converter no end. You need a unit specifically rated for smart alternators or you'll get weird behaviour and potentially stress the alternator.
Anyone else running DC-DC off a vehicle alternator for LiFePO4? Curious what amperage people are going for — tempted to upsize mine but worried about cooking the alternator on longer cruises.