Mixed orientation works if you've thought it through properly, but I'd push back on the "more hassle" comment — depends entirely on your roof space and what you're actually trying to achieve.
On a static caravan you're not moving it daily, so the real question is: what's your winter generation priority? If you're genuinely trying to max out December/January output, east-west can help flatten the generation curve across the day. But if you've got decent south-facing space, go south-facing first — a single orientation is simpler to wire, easier to clean, and honestly more efficient in the UK's typical winter cloud.
What's your latitude and how much roof space have you got? That'll make a real difference. Also — 5kW of panels is solid for a static setup, but what's your battery capacity and winter usage looking like? I've got a similar-spec boat system and the panels are only half the equation; I found out the hard way that oversizing panels without matching battery and loads is a false economy.
The 16x Renogy units are decent modules. Just make sure your MPPT controller can handle the actual voltage and current you