Had this exact issue last winter with my Orion-Tr Smart 30A in the van. Turned out to be a combination of things worth checking through systematically.
First thing to look at is your input voltage threshold. When the engine's under load — climbing a hill, running the AC, towing — the alternator output can sag noticeably. The Orion defaults to cutting out around 11.5–12V on the input side. If your voltage is dipping below that under load, it'll shut off. You can adjust this in the VictronConnect app; I dropped mine to 11V and it sorted most of the cutting out.
Second, check your wiring gauge and connections. A high-resistance connection anywhere on the input side will cause voltage drop that the unit reads as low input. I found a poorly crimped lug on my leisure battery positive that was losing nearly 0.8V under load. Infuriating to diagnose but worth checking every joint with a multimeter under load.
Third — is yours isolated or non-isolated? If non-isolated, make sure your chassis grounds are solid. A dodgy ground path can cause all sorts of strange behaviour including nuisance shutdowns.
Also worth enabling the engine detection via alternator voltage rather than relying on a D+ signal if you haven't already. Some vans (Transit Customs in particular) have slightly odd ignition signal behaviour that confuses the unit.
What vehicle are you running it in, and have you had a chance to log the input voltage during one of the cutouts? VictronConnect will show you historical data if you've got it connected via Bluetooth — that'd narrow it down considerably.