Looking at your Sprinter situation — what's your actual power draw like? That's the real decider here.
I'm running 24V in a cabin setup with modest loads (fridge, lighting, occasional power tools) and it's been bulletproof reliable. Wiring's cheaper, component selection's wider, and you can push decent amperage without needing industrial-grade cable runs.
But — and this matters — if you're planning to add serious kit later (multiple inverters, high-draw compressor fridge, workshop equipment), 48V might save you headaches down the line. Cable losses become genuinely noticeable on 12V once you're over a few kW.
Key question: are you sticking with lead-acid or going lithium? That changes the calculus. With a proper LiFePO₄ bank, 48V becomes much more sensible because you're spreading the amperage load. With lead-acid, 24V's probably your sweet spot for a Sprinter — you won't hit those ridiculous discharge rates that turn batteries into expensive toast.
What's your current consumption looking like on that 100